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What is HARVONI?

HARVONI is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype (GT) 1, 4, 5 or 6 infection with or without cirrhosis (compensated). In those with GT 1 and advanced cirrhosis (decompensated) or with GT 1 or 4 with or without cirrhosis (compensated) who have had a liver transplant, HARVONI is used with ribavirin.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about HARVONI?

HARVONI can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting HARVONI treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with HARVONI. This may cause serious liver problems, including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking HARVONI.

  • What should I tell my healthcare provider before taking HARVONI?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have severe kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if HARVONI will harm your unborn baby or pass into your breast milk. If you take HARVONI with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. HARVONI and certain other medicines may affect each other, or may cause side effects.

  • What are the possible side effects of HARVONI?

    Serious side effects may also include:

  • Slow heart rate (bradycardia): HARVONI, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate, which in some cases has led to death or the need for a pacemaker. Get medical help right away if you take amiodarone with HARVONI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
    The most common side effects of HARVONI include tiredness, headache, and weakness.

  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

    Please see Important Facts about HARVONI including Important Warning on hepatitis B reactivation.



    HARVONI and the HARVONI logo are trademarks of Gilead Sciences, Inc. or its related companies.

    Older Female Hep C Patient Older Female Hep C Patient Older Female Hep C Patient Older Female Hep C Patient

    RISKS OF HEP C

    HEP C:危害

    一个人可以患有丙型肝炎(丙肝)数年甚至数十年都不会有恶心的感觉。因此,许多人患有丙肝也没有察觉出来,因此,没有采取积极的治疗。如果不及时治疗,丙肝Hep C会严重损害您的肝脏,最终导致肝脏死亡。事实上,Hep C杀死的美国人比向疾病控制和预防中心报告的任何其他传染病都要多。


    查看可能发生的症状(并可能表示肝脏受损)。



    您的Hep C专科医生可通过验血,超声或肝活检确定纤维化评分(F0 - F4)。这些测试的评分估计肝脏中的瘢痕形成量。纤维化评分越高,您就越有可能发生严重的肝损伤。

    重要安全

    信息

    关于吉三代,我应该了解哪些最重要的信息?

    吉三代可引起严重的副作用,包括:

  • 乙型肝炎病毒再激活: 在开始EPCLUSA治疗之前,您的医疗保健提供者将进行血液检查以检查乙型肝炎感染。如果您曾患过乙型肝炎,乙型肝炎病毒可能会在使用EPCLUSA治疗期间和之后再次活跃起来。这可能导致严重的肝脏问题,包括肝功能衰竭和死亡。如果您有风险,您的医疗服务提供者将在服用EPCLUSA期间和之后对您进行监控。

  • 更多>>


    丙型肝炎感染会影响肝脏以外的其他器官吗?

  • 丙型肝炎感染的大多数症状和体征与肝脏有关。比较罕见的是,丙型肝炎感染可以影响肝脏以外的器官。 丙型肝炎感染可能导致身体产生称为冷球蛋白的异常抗体。冷球蛋白引起动脉炎症(血管炎)。这可能会损伤皮肤,关节和肾脏。患有冷球蛋白症的患者可能会有以下症状: 关节疼痛, 关节炎, 腿上有凸起的紫色皮疹 全身疼痛或身体肿胀。 此外,患有冷球蛋白症的感染者可能会出现雷诺氏现象,其中手指和脚趾会变色(白色,紫色,然后是红色),并在寒冷的温度下变得疼痛。

  • 点击使用和有关EPCLUSA的重要安全信息,包括乙型肝炎再激活的重要警告。