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What is HARVONI?

HARVONI is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype (GT) 1, 4, 5 or 6 infection with or without cirrhosis (compensated). In those with GT 1 and advanced cirrhosis (decompensated) or with GT 1 or 4 with or without cirrhosis (compensated) who have had a liver transplant, HARVONI is used with ribavirin.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about HARVONI?

HARVONI can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting HARVONI treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with HARVONI. This may cause serious liver problems, including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking HARVONI.

  • What should I tell my healthcare provider before taking HARVONI?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have severe kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if HARVONI will harm your unborn baby or pass into your breast milk. If you take HARVONI with ribavirin, you should also read the ribavirin Medication Guide for important pregnancy-related information.

  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. HARVONI and certain other medicines may affect each other, or may cause side effects.

  • What are the possible side effects of HARVONI?

    Serious side effects may also include:

  • Slow heart rate (bradycardia): HARVONI, when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate, which in some cases has led to death or the need for a pacemaker. Get medical help right away if you take amiodarone with HARVONI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
    The most common side effects of HARVONI include tiredness, headache, and weakness.

  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

    Please see Important Facts about HARVONI including Important Warning on hepatitis B reactivation.



    HARVONI and the HARVONI logo are trademarks of Gilead Sciences, Inc. or its related companies.

    Older Female Hep C Patient Older Female Hep C Patient Older Female Hep C Patient Older Female Hep C Patient

    WHAT IS HEP C?

    丙肝影响数百万人

    丙型肝炎(Hep C)是一种传染性肝病,通过与患有该病毒的人的血液接触而传播。


    2.4 MILLION

    people with Hep C

    疾病进展缓慢,通常没有症状。 这就是为什么许多患有丙肝的人不知道他们有这种情况。 许多人不知道它可以治愈。.


    了解丙肝的风险因素


    不同分型的Hep C.

    丙型肝炎病毒感染(Hep C)有不同的基因分型。基因型1-6是最常见的。对于患有丙型肝炎病毒(Hep C)的人来说,知道丙肝的具体分型是非常重要的,因为只有知道了病毒的基因分型,才能确定方案和药品剂量。令人兴奋的好消息是,所有6种主要的丙型病毒(Hep C)基因型都可以治疗和治愈。

    治愈意味着在治疗完成3个月后测量血液中未检测到Hep C病毒。

    6 MAIN GENOTYPES

    of Hep C

    什么药物治愈丙型

    肝炎感染?

  • 干扰素:例如Roferon-A和Infergen,以及聚乙二醇化干扰素,例如Peg-Intron T,Pegasys,多年来一直是治疗的主要方法。干扰素产生持续的病毒反应(SVR或治愈)高达15%。之后,peglatedll形式产生50%-80%的SVR。注射这些药物,有许多不良反应,需要经常监测,并且经常与口服利巴韦林合用,导致贫血。治疗持续时间最长可达48周。

  • 建议药品:吉三代,吉三代已经成为了治疗丙肝的标准药物。这种药通过口服,耐受性良好,并且治愈超过98%的患者。疗时间也要短得多,通常为12周,具体取决于药物和基因型。


  • 丙型肝炎(潜伏期)是多长时间?

  • 很难确定丙型肝炎的潜伏期是多久,因为大多数感染丙型肝炎的人在感染早期没有症状。感染后,早期出现症状的人(平均2至12周,但可能更长)会出现轻度胃肠道症状,可能无法及时就诊。

  • 丙型肝炎治疗后如何进行监测?

  • 患者是否成功被治愈,可以通过病毒含量也判断。如果已经治愈(治疗后检测不到病毒含量)。除非患者患有肝硬化,否则不建议进行进一步的额外检测。对于那些未治愈的人需要继续监测肝病及其并发症的进展。 虽然治愈可以消除丙型肝炎引起的纤维化恶化,但并发症仍可能影响肝硬化患者。这些人仍然需要定期筛查肝癌以及监测可能出血的食管静脉曲张。 由于治疗慢性丙型肝炎后,可能再次激活乙型肝炎,因此在丙型肝炎治愈后,还要检测肝炎症状。

  • 点击使用和有关EPCLUSA的重要安全信息,包括乙型肝炎再激活的重要警告。